Defining the Antigen Determinant for T-Cell-Mediated Contact Dermatitis Using p-Phenylenediamine: A Gateway to Chemical Immunology.
J Invest Dermatol. 2010 Mar;130(3):641-3
Authors: Elliott G, Das PK
By binding to host proteins to form haptens, low-molecular-weight compounds such as p-phenylenediamine (PPD) can become contact sensitizers. In this issue, Jenkinson et al. demonstrate that it is possible to use chemically characterized hapten-protein complexes to analyze T-cell responses in cells from allergic individuals. This approach may help in the development of in vitro tests for diagnosing contact dermatitis.
PMID: 20145640 [PubMed - in process]