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Defining the Antigen Determinant for T-Cell-Mediated Contact Dermatitis Using p-Phenylenediamine: A Gateway to Chemical Immunology.

February 12th, 2010 · No Comments

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Defining the Antigen Determinant for T-Cell-Mediated Contact Dermatitis Using p-Phenylenediamine: A Gateway to Chemical Immunology.

J Invest Dermatol. 2010 Mar;130(3):641-3

Authors: Elliott G, Das PK

By binding to host proteins to form haptens, low-molecular-weight compounds such as p-phenylenediamine (PPD) can become contact sensitizers. In this issue, Jenkinson et al. demonstrate that it is possible to use chemically characterized hapten-protein complexes to analyze T-cell responses in cells from allergic individuals. This approach may help in the development of in vitro tests for diagnosing contact dermatitis.

PMID: 20145640 [PubMed - in process]

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